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(343) 333-44-33
г. Екатеринбург, 22-го Партсъезда, 50
Генотипы и мутации, приводящие к резистентности к изониазиду (INH), рифампицину (RIF), аминогликозидам (AG) и фторхинолонам (FQ), у клинических изолятов Mycobacterium tuberculosis Mycobacterium tuberculosis clinical isolates' genotypes and mutations, conferring resistance to antituberculosis drugs  (изоляты от ВИЧ+ больных / isolated from HIV+ patients)
  Лабораторный номер / Laboratory № Мутации, связанные с резистентностью к: / Mutations conferring resistance to:
RIF INH   EMB FQ  AG Генотип / Genotype
rpoB katG inhA ahpC
embB gyrA  gyrB      eis rrs
1 A1589-19 Ser531Leu Ser315Thr wt wt Met306Val Asp94Gly-Ser95Thr wt wt wt B0 / W148 Beijing
2 A3455-19 Ser531Leu Ser315Thr wt wt Asn296His wt wt wt wt B0 / W148 Beijing
3 A3693-19 Ser531Leu Ser315Thr wt wt Met306Val Ala90Val-Ser91Pro wt wt wt B0 / W148 Beijing
4 A2958-19 Ser531Leu Ser315Thr wt wt Asn296His wt wt wt wt B0 / W148 Beijing
5 A3055-19 Ser531Leu Ser315Thr wt wt Met306Val wt wt wt wt B0 / W148 Beijing
6 A5574-19 Ser531Leu Ser315Thr wt wt Met306Leu Asp94Gly-Ser95Thr wt Gly10Ala wt B0 / W148 Beijing
7 A4692-19 Ser531Leu Ser315Thr wt wt Asn296His wt wt wt wt B0 / W148 Beijing
8 A6561-19 Ser531Leu Ser315Thr wt wt Met306Val Ala90Val-Ser91Pro wt wt wt B0 / W148 Beijing
9 A8058-19 Ser531Leu Ser315Thr wt wt Met306Leu wt wt wt wt B0 / W148 Beijing
10 A0110-20 Ser531Leu Ser315Thr T15A wt Asn296His Ala90Val-Ser91Pro wt Gly10Ala wt B0 / W148 Beijing
11 A0023-20 Ser531Leu Ser315Thr wt wt Met306Val wt wt wt wt B0 / W148 Beijing
12 A0033-20 Ser531Leu Ser315Thr wt wt Met306Leu Asp94Ala-Ser95Thr wt Cys12Thr wt B0 / W148 Beijing
13 U5848-19 Ser531Leu Ser315Thr wt wt Met306Val Asp94Gly-Ser95Thr wt Gly10Ala wt B0 / W148 Beijing
14 U6539-19 Ser531Leu Ser315Thr wt wt Ser297Ala Ala90Val-Ser91Pro wt Gly10Ala wt B0 / W148 Beijing
15 U6911-19 Ser531Leu Ser315Thr wt wt Met306Val wt wt wt wt B0 / W148 Beijing
16 U7467-19 Ser531Leu Ser315Thr wt wt Asn296His wt wt wt wt B0 / W148 Beijing
17 U8396-19 Ser531Leu Ser315Thr wt wt Asn296His Asp94Ala-Ser95Thr wt wt wt B0 / W148 Beijing
18 U1739-20 Ser531Leu Ser315Thr wt wt Met306Val wt wt wt wt B0 / W148 Beijing
19 U3455-19 Ser531Leu Ser315Thr wt wt Met306Leu Asp94Asn-Ser95Thr wt Cys14Thr wt B0 / W148 Beijing
20 U3893-19 Ser531Leu Ser315Thr wt wt Met306Val wt wt wt wt B0 / W148 Beijing
21 U5974-19 Ser531Leu Ser315Thr wt wt Asn296His wt wt wt wt B0 / W148 Beijing
22 U2561-20 Ser531Leu Ser315Thr wt wt Met306Val Asp94Gly-Ser95Thr wt wt wt B0 / W148 Beijing
23 U00123-20 Ser531Leu Ser315Thr wt wt Met306Val Asp94Gly-Ser95Thr wt Cys14Thr wt B0 / W148 Beijing
24 U00133-20 Ser531Leu Ser315Thr wt wt Asn296His wt wt wt wt B0 / W148 Beijing
25 U5947-19 Ser531Leu Ser315Thr wt wt Met306Leu Asp94Asn-Ser95Thr wt wt wt B0 / W148 Beijing
26 U5058-19 Ser531Leu Ser315Thr wt wt Met306Val wt wt wt wt B0 / W148 Beijing
27 U5587-19 Ser531Leu Ser315Thr wt wt wt Asp94Gly-Ser95Thr wt wt wt Beijing
28 U6661-19 Ser531Leu Ser315Thr wt wt Met306Leu wt wt wt wt Beijing
29 U6670-19 wt Ser315Arg  wt wt Met306Val wt wt wt wt Beijing
30 U7121-19 wt wt wt wt wt wt wt wt wt Beijing
31 U7335-19 wt wt wt wt wt wt wt wt wt Beijing
32 U8271-19 Ser531Leu Ser315Thr wt wt Met306Val wt wt wt wt Beijing
33 U2270-20 wt Ser315Thr wt wt Met306Leu Asp94Gly-Ser95Thr wt   Ala1401Gly Beijing
34 U1204-19 Ser531Leu Ser315Thr wt wt wt wt wt wt wt Beijing
35 U3563-19 wt Ser315Thr wt wt Met306Val wt wt wt wt Beijing
36 U3189-19 wt Ser315Thr wt wt Met306Val wt wt wt wt Beijing
37 U2816-19 wt Ser315Thr wt wt Met306Leu wt wt wt Ala1401Gly Beijing
38 U2952-19 Ser531Leu Ser315Thr wt wt Met306Val Asp94Asn-Ser95Thr wt wt wt Beijing
39 U4363-19 wt Ser315Thr wt wt Met306Leu wt wt wt wt Beijing
40 U5057-19 wt Ser315Thr wt wt wt wt wt wt wt Beijing
41 U5973-19 wt Ser315Thr wt wt Met306Val wt wt wt wt Beijing
42 U5035-19 Ser531Leu Ser315Thr wt wt Met306Leu Asp94Asn-Ser95Thr wt Cys14Thr wt Beijing
43 U6904-19 Ser531Leu Ser315Thr wt wt   wt wt wt wt Beijing
44 U7033-19 Ser531Leu Ser315Thr wt wt Met306Leu Ala90Val-Ser91Pro wt Gly10Ala wt Beijing
45 U7157-19 wt Ser315Thr wt wt Met306Val wt wt wt wt Beijing
46 U7156-19 Ser531Leu Ser315Thr wt wt wt wt wt wt wt Beijing
47 U5610-19 wt Ser315Thr wt wt wt wt wt wt wt Beijing
48 U5617-19 wt Ser315Thr wt wt wt wt wt wt wt Beijing
49 U5671-19 Ser531Leu Ser315Thr wt wt Asp354Ala wt wt Gly10Ala wt Beijing
50 U5707-19 Ser531Leu Ser315Thr wt wt wt wt wt wt wt Beijing
51 U00132-20 Ser531Leu Ser315Thr wt wt wt wt wt Gly37Thr wt Beijing
52 U00196-20 wt Ser315Thr wt wt wt wt wt wt wt Beijing
53 U5695-19 Ser531Leu Ser315Thr wt wt Met306Val wt wt wt Ala1401Gly Beijing
54 U5593-19 Ser531Leu Ser315Thr wt wt Met306Val wt wt wt wt Beijing
55 U5391-19 wt Ser315Thr wt wt wt wt wt wt wt Beijing
56 U5312-19 wt Ser315Thr wt wt Asp354Ala wt wt wt wt Beijing
57 A2204-19 Ser531Leu Ser315Thr wt wt Met306Leu wt wt wt wt Beijing
58 A1989-19 wt Ser315Thr wt wt wt wt wt wt wt Beijing
59 A2364-19 Ser531Leu Ser315Thr wt wt Glu378Ala wt wt wt wt Beijing
60 A5576-19 wt Ser315Thr wt wt wt wt wt wt wt Beijing
61 A5473-19 Ser531Leu Ser315Thr wt wt Met306Val Asp94Tyr-Ser95Thr wt Cys14Thr wt Beijing
62 A5935-19 wt Ser315Thr wt wt Asp354Ala wt wt wt wt Beijing
63 A6771-19 Ser531Leu Ser315Thr wt wt Met306Val wt wt wt wt Beijing
64 A7404-19 wt wt wt wt wt wt wt wt wt Beijing
65 A7233-19 wt wt wt wt wt wt wt wt wt Beijing
66 A7557-19 Ser531Leu wt T15A wt Asp354Ala wt wt wt wt Beijing
67 A7556-19 Ser531Leu wt wt wt Asp354Ala wt wt wt wt Beijing
68 A5617-19 Ser531Leu wt wt wt Met306Val wt wt wt Ala1401Gly Beijing
69 A5671-19 wt Ser315Thr wt wt Met306Val wt wt wt wt Beijing
70 A5707-19 wt Ser315Thr wt wt wt wt wt wt wt Beijing
71 A0032-20 Ser531Leu Ser315Thr wt wt Met306Val wt wt wt wt Beijing
72 A0096-20 Ser531Leu wt wt wt wt wt wt wt wt Beijing
73 A0128-20 Ser531Leu wt wt wt wt wt wt wt wt Beijing
74 A0141-20 wt Ser315Thr wt wt Ala313Val wt wt wt wt Beijing
75 A0142-20 Leu511Pro Ser315Thr wt wt Met306Val wt wt wt wt Beijing
76 A4895-19 wt Ser315Thr wt wt   wt wt wt wt Beijing
77 A7845-19 wt wt wt wt wt wt wt wt wt Beijing
78 A0113-20 wt wt wt wt wt wt wt wt wt Beijing
79 A0101-20 wt Ser315Thr wt wt Gly406Ser wt wt wt wt Beijing
80 A1450-20 Ser531Leu Ser315Thr wt wt Ala313Val wt wt wt Ala1401Gly Beijing
81 U1550-19 wt Ser315Thr wt wt Gly406Ser wt wt wt wt Beijing
82 U2479-20 Ser531Leu Ser315Thr wt wt wt wt wt wt wt Beijing
83 U2150-20 wt wt wt wt wt wt wt wt wt Beijing
84 U6232-19 wt wt wt wt wt wt wt wt wt Beijing
85 A1753-19 wt Ser315Thr wt wt   wt wt wt wt Beijing
86 A1875-19 wt wt wt wt wt wt wt wt wt Beijing
87 A2064-19 wt wt wt wt wt wt wt wt wt Beijing
88 A2058-19 Asp516Ala Ser315Thr wt wt Glu378Ala wt wt wt Ala1401Gly Beijing
89 A2090-19 wt wt wt wt wt wt wt wt wt Beijing
90 A5199-19 wt Ser315Thr wt wt   wt wt wt wt Beijing
91 A6930-19 wt wt wt wt wt wt wt wt wt Beijing
92 A7025-19 wt Ser315Thr wt wt wt wt wt wt wt Beijing
93 A7232-19 wt wt wt wt wt wt wt wt wt Beijing
94 A6924-19 wt wt wt wt   wt wt wt wt Beijing
95 A8060-19 wt wt wt wt wt wt wt wt wt Beijing
96 A8059-19 wt Ser315Thr wt wt Ala313Val wt wt wt wt Beijing
97 A1458-20 wt wt wt wt wt wt wt wt wt LAM
98 A5720-19 wt wt wt wt wt wt wt wt wt LAM
99 U2720-20 wt wt wt wt wt wt wt wt wt LAM
100 A1876-19 wt wt T15A wt wt wt wt wt wt LAM
101 A1461-19 Leu511Pro wt wt wt Met306Val wt wt wt wt LAM
102 A1479-19 wt wt wt wt wt wt wt wt wt LAM
103 A1481-20 His526Asn wt wt wt Met306Val wt wt wt wt LAM
104 A1877-19 wt wt T15A wt wt wt wt wt wt LAM
105 A1590-19 wt wt wt wt wt wt wt wt wt LAM
106 A2198-19 wt wt wt wt wt wt wt wt wt LAM
107 A0097-20 wt wt wt wt wt wt wt wt wt T 1
108 A0139-20 wt wt wt wt wt wt wt wt wt T 1
109 U6172-19 wt wt wt wt wt wt wt wt wt T 1
110 A3695-19 wt wt wt wt wt wt wt wt wt Ural
111 A1754-19 Asp516Ala wt wt wt wt wt wt wt wt Ural
112 A0039-20 wt wt wt wt wt wt wt wt wt Ural
113 U6151-19 wt wt wt wt wt wt wt wt wt Ural
114 U5054-19 wt wt wt wt   Asp94Ala-Ser95Thr wt wt wt Ural
115 U5055-19 wt wt wt wt   wt wt wt wt Ural
116 U00139-20 wt wt wt wt   wt wt wt Gly10Ala Ural
117 A2751-19 wt wt wt wt Met306Val wt wt wt wt Ural
118 A2563-19 wt wt wt wt   wt wt wt wt Ural
119 A2805-19 wt wt wt wt   wt wt wt wt Ural
120 A2401-19 wt wt wt wt   wt wt wt wt Ural
121 A3191-19 wt wt wt wt   wt wt wt wt Ural
122 A4456-19 wt wt wt wt   Ala90Val-Ser91Pro wt wt wt Ural
123 A2816-19 wt wt wt wt   wt wt wt wt Ural
124 A2954-19 wt wt wt wt   wt wt wt Cys12Thr Ural
125 A2566-19 wt wt wt wt   Asp94Asn-Ser95Thr wt wt wt Ural
126 A2798-19 wt wt wt wt   wt wt wt wt Ural
127 A3701-19 wt wt wt wt   wt wt wt wt Ural
128 A3153-19 wt wt wt wt   wt wt wt wt Ural
129 A1750-20 wt wt wt wt wt wt wt wt wt EAL