| Генотипы и мутации, приводящие к резистентности к изониазиду (INH), рифампицину (RIF), аминогликозидам (AG) и фторхинолонам (FQ), у клинических изолятов Mycobacterium tuberculosis Mycobacterium tuberculosis clinical isolates' genotypes and mutations, conferring resistance to antituberculosis drugs (изоляты от ВИЧ+ больных / isolated from HIV+ patients) | |||||||||||
| № | Лабораторный номер / Laboratory № | Мутации, связанные с резистентностью к: / Mutations conferring resistance to: | |||||||||
| RIF | INH | EMB | FQ | AG | Генотип / Genotype | ||||||
| rpoB | katG | inhA | ahpC |
embB | gyrA | gyrB | eis | rrs | |||
| 1 | A1589-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | Asp94Gly-Ser95Thr | wt | wt | wt | B0 / W148 Beijing |
| 2 | A3455-19 | Ser531Leu | Ser315Thr | wt | wt | Asn296His | wt | wt | wt | wt | B0 / W148 Beijing |
| 3 | A3693-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | Ala90Val-Ser91Pro | wt | wt | wt | B0 / W148 Beijing |
| 4 | A2958-19 | Ser531Leu | Ser315Thr | wt | wt | Asn296His | wt | wt | wt | wt | B0 / W148 Beijing |
| 5 | A3055-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | B0 / W148 Beijing |
| 6 | A5574-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Leu | Asp94Gly-Ser95Thr | wt | Gly10Ala | wt | B0 / W148 Beijing |
| 7 | A4692-19 | Ser531Leu | Ser315Thr | wt | wt | Asn296His | wt | wt | wt | wt | B0 / W148 Beijing |
| 8 | A6561-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | Ala90Val-Ser91Pro | wt | wt | wt | B0 / W148 Beijing |
| 9 | A8058-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Leu | wt | wt | wt | wt | B0 / W148 Beijing |
| 10 | A0110-20 | Ser531Leu | Ser315Thr | T15A | wt | Asn296His | Ala90Val-Ser91Pro | wt | Gly10Ala | wt | B0 / W148 Beijing |
| 11 | A0023-20 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | B0 / W148 Beijing |
| 12 | A0033-20 | Ser531Leu | Ser315Thr | wt | wt | Met306Leu | Asp94Ala-Ser95Thr | wt | Cys12Thr | wt | B0 / W148 Beijing |
| 13 | U5848-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | Asp94Gly-Ser95Thr | wt | Gly10Ala | wt | B0 / W148 Beijing |
| 14 | U6539-19 | Ser531Leu | Ser315Thr | wt | wt | Ser297Ala | Ala90Val-Ser91Pro | wt | Gly10Ala | wt | B0 / W148 Beijing |
| 15 | U6911-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | B0 / W148 Beijing |
| 16 | U7467-19 | Ser531Leu | Ser315Thr | wt | wt | Asn296His | wt | wt | wt | wt | B0 / W148 Beijing |
| 17 | U8396-19 | Ser531Leu | Ser315Thr | wt | wt | Asn296His | Asp94Ala-Ser95Thr | wt | wt | wt | B0 / W148 Beijing |
| 18 | U1739-20 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | B0 / W148 Beijing |
| 19 | U3455-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Leu | Asp94Asn-Ser95Thr | wt | Cys14Thr | wt | B0 / W148 Beijing |
| 20 | U3893-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | B0 / W148 Beijing |
| 21 | U5974-19 | Ser531Leu | Ser315Thr | wt | wt | Asn296His | wt | wt | wt | wt | B0 / W148 Beijing |
| 22 | U2561-20 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | Asp94Gly-Ser95Thr | wt | wt | wt | B0 / W148 Beijing |
| 23 | U00123-20 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | Asp94Gly-Ser95Thr | wt | Cys14Thr | wt | B0 / W148 Beijing |
| 24 | U00133-20 | Ser531Leu | Ser315Thr | wt | wt | Asn296His | wt | wt | wt | wt | B0 / W148 Beijing |
| 25 | U5947-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Leu | Asp94Asn-Ser95Thr | wt | wt | wt | B0 / W148 Beijing |
| 26 | U5058-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | B0 / W148 Beijing |
| 27 | U5587-19 | Ser531Leu | Ser315Thr | wt | wt | wt | Asp94Gly-Ser95Thr | wt | wt | wt | Beijing |
| 28 | U6661-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Leu | wt | wt | wt | wt | Beijing |
| 29 | U6670-19 | wt | Ser315Arg | wt | wt | Met306Val | wt | wt | wt | wt | Beijing |
| 30 | U7121-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 31 | U7335-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 32 | U8271-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | Beijing |
| 33 | U2270-20 | wt | Ser315Thr | wt | wt | Met306Leu | Asp94Gly-Ser95Thr | wt | Ala1401Gly | Beijing | |
| 34 | U1204-19 | Ser531Leu | Ser315Thr | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 35 | U3563-19 | wt | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | Beijing |
| 36 | U3189-19 | wt | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | Beijing |
| 37 | U2816-19 | wt | Ser315Thr | wt | wt | Met306Leu | wt | wt | wt | Ala1401Gly | Beijing |
| 38 | U2952-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | Asp94Asn-Ser95Thr | wt | wt | wt | Beijing |
| 39 | U4363-19 | wt | Ser315Thr | wt | wt | Met306Leu | wt | wt | wt | wt | Beijing |
| 40 | U5057-19 | wt | Ser315Thr | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 41 | U5973-19 | wt | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | Beijing |
| 42 | U5035-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Leu | Asp94Asn-Ser95Thr | wt | Cys14Thr | wt | Beijing |
| 43 | U6904-19 | Ser531Leu | Ser315Thr | wt | wt | wt | wt | wt | wt | Beijing | |
| 44 | U7033-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Leu | Ala90Val-Ser91Pro | wt | Gly10Ala | wt | Beijing |
| 45 | U7157-19 | wt | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | Beijing |
| 46 | U7156-19 | Ser531Leu | Ser315Thr | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 47 | U5610-19 | wt | Ser315Thr | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 48 | U5617-19 | wt | Ser315Thr | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 49 | U5671-19 | Ser531Leu | Ser315Thr | wt | wt | Asp354Ala | wt | wt | Gly10Ala | wt | Beijing |
| 50 | U5707-19 | Ser531Leu | Ser315Thr | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 51 | U00132-20 | Ser531Leu | Ser315Thr | wt | wt | wt | wt | wt | Gly37Thr | wt | Beijing |
| 52 | U00196-20 | wt | Ser315Thr | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 53 | U5695-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | Ala1401Gly | Beijing |
| 54 | U5593-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | Beijing |
| 55 | U5391-19 | wt | Ser315Thr | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 56 | U5312-19 | wt | Ser315Thr | wt | wt | Asp354Ala | wt | wt | wt | wt | Beijing |
| 57 | A2204-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Leu | wt | wt | wt | wt | Beijing |
| 58 | A1989-19 | wt | Ser315Thr | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 59 | A2364-19 | Ser531Leu | Ser315Thr | wt | wt | Glu378Ala | wt | wt | wt | wt | Beijing |
| 60 | A5576-19 | wt | Ser315Thr | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 61 | A5473-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | Asp94Tyr-Ser95Thr | wt | Cys14Thr | wt | Beijing |
| 62 | A5935-19 | wt | Ser315Thr | wt | wt | Asp354Ala | wt | wt | wt | wt | Beijing |
| 63 | A6771-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | Beijing |
| 64 | A7404-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 65 | A7233-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 66 | A7557-19 | Ser531Leu | wt | T15A | wt | Asp354Ala | wt | wt | wt | wt | Beijing |
| 67 | A7556-19 | Ser531Leu | wt | wt | wt | Asp354Ala | wt | wt | wt | wt | Beijing |
| 68 | A5617-19 | Ser531Leu | wt | wt | wt | Met306Val | wt | wt | wt | Ala1401Gly | Beijing |
| 69 | A5671-19 | wt | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | Beijing |
| 70 | A5707-19 | wt | Ser315Thr | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 71 | A0032-20 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | Beijing |
| 72 | A0096-20 | Ser531Leu | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 73 | A0128-20 | Ser531Leu | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 74 | A0141-20 | wt | Ser315Thr | wt | wt | Ala313Val | wt | wt | wt | wt | Beijing |
| 75 | A0142-20 | Leu511Pro | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | Beijing |
| 76 | A4895-19 | wt | Ser315Thr | wt | wt | wt | wt | wt | wt | Beijing | |
| 77 | A7845-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 78 | A0113-20 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 79 | A0101-20 | wt | Ser315Thr | wt | wt | Gly406Ser | wt | wt | wt | wt | Beijing |
| 80 | A1450-20 | Ser531Leu | Ser315Thr | wt | wt | Ala313Val | wt | wt | wt | Ala1401Gly | Beijing |
| 81 | U1550-19 | wt | Ser315Thr | wt | wt | Gly406Ser | wt | wt | wt | wt | Beijing |
| 82 | U2479-20 | Ser531Leu | Ser315Thr | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 83 | U2150-20 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 84 | U6232-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 85 | A1753-19 | wt | Ser315Thr | wt | wt | wt | wt | wt | wt | Beijing | |
| 86 | A1875-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 87 | A2064-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 88 | A2058-19 | Asp516Ala | Ser315Thr | wt | wt | Glu378Ala | wt | wt | wt | Ala1401Gly | Beijing |
| 89 | A2090-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 90 | A5199-19 | wt | Ser315Thr | wt | wt | wt | wt | wt | wt | Beijing | |
| 91 | A6930-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 92 | A7025-19 | wt | Ser315Thr | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 93 | A7232-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 94 | A6924-19 | wt | wt | wt | wt | wt | wt | wt | wt | Beijing | |
| 95 | A8060-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
| 96 | A8059-19 | wt | Ser315Thr | wt | wt | Ala313Val | wt | wt | wt | wt | Beijing |
| 97 | A1458-20 | wt | wt | wt | wt | wt | wt | wt | wt | wt | LAM |
| 98 | A5720-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | LAM |
| 99 | U2720-20 | wt | wt | wt | wt | wt | wt | wt | wt | wt | LAM |
| 100 | A1876-19 | wt | wt | T15A | wt | wt | wt | wt | wt | wt | LAM |
| 101 | A1461-19 | Leu511Pro | wt | wt | wt | Met306Val | wt | wt | wt | wt | LAM |
| 102 | A1479-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | LAM |
| 103 | A1481-20 | His526Asn | wt | wt | wt | Met306Val | wt | wt | wt | wt | LAM |
| 104 | A1877-19 | wt | wt | T15A | wt | wt | wt | wt | wt | wt | LAM |
| 105 | A1590-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | LAM |
| 106 | A2198-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | LAM |
| 107 | A0097-20 | wt | wt | wt | wt | wt | wt | wt | wt | wt | T 1 |
| 108 | A0139-20 | wt | wt | wt | wt | wt | wt | wt | wt | wt | T 1 |
| 109 | U6172-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | T 1 |
| 110 | A3695-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Ural |
| 111 | A1754-19 | Asp516Ala | wt | wt | wt | wt | wt | wt | wt | wt | Ural |
| 112 | A0039-20 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Ural |
| 113 | U6151-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Ural |
| 114 | U5054-19 | wt | wt | wt | wt | Asp94Ala-Ser95Thr | wt | wt | wt | Ural | |
| 115 | U5055-19 | wt | wt | wt | wt | wt | wt | wt | wt | Ural | |
| 116 | U00139-20 | wt | wt | wt | wt | wt | wt | wt | Gly10Ala | Ural | |
| 117 | A2751-19 | wt | wt | wt | wt | Met306Val | wt | wt | wt | wt | Ural |
| 118 | A2563-19 | wt | wt | wt | wt | wt | wt | wt | wt | Ural | |
| 119 | A2805-19 | wt | wt | wt | wt | wt | wt | wt | wt | Ural | |
| 120 | A2401-19 | wt | wt | wt | wt | wt | wt | wt | wt | Ural | |
| 121 | A3191-19 | wt | wt | wt | wt | wt | wt | wt | wt | Ural | |
| 122 | A4456-19 | wt | wt | wt | wt | Ala90Val-Ser91Pro | wt | wt | wt | Ural | |
| 123 | A2816-19 | wt | wt | wt | wt | wt | wt | wt | wt | Ural | |
| 124 | A2954-19 | wt | wt | wt | wt | wt | wt | wt | Cys12Thr | Ural | |
| 125 | A2566-19 | wt | wt | wt | wt | Asp94Asn-Ser95Thr | wt | wt | wt | Ural | |
| 126 | A2798-19 | wt | wt | wt | wt | wt | wt | wt | wt | Ural | |
| 127 | A3701-19 | wt | wt | wt | wt | wt | wt | wt | wt | Ural | |
| 128 | A3153-19 | wt | wt | wt | wt | wt | wt | wt | wt | Ural | |
| 129 | A1750-20 | wt | wt | wt | wt | wt | wt | wt | wt | wt | EAL |







