Генотипы и мутации, приводящие к резистентности к изониазиду (INH), рифампицину (RIF), аминогликозидам (AG) и фторхинолонам (FQ), у клинических изолятов Mycobacterium tuberculosis Mycobacterium tuberculosis clinical isolates' genotypes and mutations, conferring resistance to antituberculosis drugs (изоляты от ВИЧ+ больных / isolated from HIV+ patients) | |||||||||||
№ | Лабораторный номер / Laboratory № | Мутации, связанные с резистентностью к: / Mutations conferring resistance to: | |||||||||
RIF | INH | EMB | FQ | AG | Генотип / Genotype | ||||||
rpoB | katG | inhA | ahpC |
embB | gyrA | gyrB | eis | rrs | |||
1 | A1589-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | Asp94Gly-Ser95Thr | wt | wt | wt | B0 / W148 Beijing |
2 | A3455-19 | Ser531Leu | Ser315Thr | wt | wt | Asn296His | wt | wt | wt | wt | B0 / W148 Beijing |
3 | A3693-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | Ala90Val-Ser91Pro | wt | wt | wt | B0 / W148 Beijing |
4 | A2958-19 | Ser531Leu | Ser315Thr | wt | wt | Asn296His | wt | wt | wt | wt | B0 / W148 Beijing |
5 | A3055-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | B0 / W148 Beijing |
6 | A5574-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Leu | Asp94Gly-Ser95Thr | wt | Gly10Ala | wt | B0 / W148 Beijing |
7 | A4692-19 | Ser531Leu | Ser315Thr | wt | wt | Asn296His | wt | wt | wt | wt | B0 / W148 Beijing |
8 | A6561-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | Ala90Val-Ser91Pro | wt | wt | wt | B0 / W148 Beijing |
9 | A8058-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Leu | wt | wt | wt | wt | B0 / W148 Beijing |
10 | A0110-20 | Ser531Leu | Ser315Thr | T15A | wt | Asn296His | Ala90Val-Ser91Pro | wt | Gly10Ala | wt | B0 / W148 Beijing |
11 | A0023-20 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | B0 / W148 Beijing |
12 | A0033-20 | Ser531Leu | Ser315Thr | wt | wt | Met306Leu | Asp94Ala-Ser95Thr | wt | Cys12Thr | wt | B0 / W148 Beijing |
13 | U5848-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | Asp94Gly-Ser95Thr | wt | Gly10Ala | wt | B0 / W148 Beijing |
14 | U6539-19 | Ser531Leu | Ser315Thr | wt | wt | Ser297Ala | Ala90Val-Ser91Pro | wt | Gly10Ala | wt | B0 / W148 Beijing |
15 | U6911-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | B0 / W148 Beijing |
16 | U7467-19 | Ser531Leu | Ser315Thr | wt | wt | Asn296His | wt | wt | wt | wt | B0 / W148 Beijing |
17 | U8396-19 | Ser531Leu | Ser315Thr | wt | wt | Asn296His | Asp94Ala-Ser95Thr | wt | wt | wt | B0 / W148 Beijing |
18 | U1739-20 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | B0 / W148 Beijing |
19 | U3455-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Leu | Asp94Asn-Ser95Thr | wt | Cys14Thr | wt | B0 / W148 Beijing |
20 | U3893-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | B0 / W148 Beijing |
21 | U5974-19 | Ser531Leu | Ser315Thr | wt | wt | Asn296His | wt | wt | wt | wt | B0 / W148 Beijing |
22 | U2561-20 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | Asp94Gly-Ser95Thr | wt | wt | wt | B0 / W148 Beijing |
23 | U00123-20 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | Asp94Gly-Ser95Thr | wt | Cys14Thr | wt | B0 / W148 Beijing |
24 | U00133-20 | Ser531Leu | Ser315Thr | wt | wt | Asn296His | wt | wt | wt | wt | B0 / W148 Beijing |
25 | U5947-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Leu | Asp94Asn-Ser95Thr | wt | wt | wt | B0 / W148 Beijing |
26 | U5058-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | B0 / W148 Beijing |
27 | U5587-19 | Ser531Leu | Ser315Thr | wt | wt | wt | Asp94Gly-Ser95Thr | wt | wt | wt | Beijing |
28 | U6661-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Leu | wt | wt | wt | wt | Beijing |
29 | U6670-19 | wt | Ser315Arg | wt | wt | Met306Val | wt | wt | wt | wt | Beijing |
30 | U7121-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
31 | U7335-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
32 | U8271-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | Beijing |
33 | U2270-20 | wt | Ser315Thr | wt | wt | Met306Leu | Asp94Gly-Ser95Thr | wt | Ala1401Gly | Beijing | |
34 | U1204-19 | Ser531Leu | Ser315Thr | wt | wt | wt | wt | wt | wt | wt | Beijing |
35 | U3563-19 | wt | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | Beijing |
36 | U3189-19 | wt | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | Beijing |
37 | U2816-19 | wt | Ser315Thr | wt | wt | Met306Leu | wt | wt | wt | Ala1401Gly | Beijing |
38 | U2952-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | Asp94Asn-Ser95Thr | wt | wt | wt | Beijing |
39 | U4363-19 | wt | Ser315Thr | wt | wt | Met306Leu | wt | wt | wt | wt | Beijing |
40 | U5057-19 | wt | Ser315Thr | wt | wt | wt | wt | wt | wt | wt | Beijing |
41 | U5973-19 | wt | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | Beijing |
42 | U5035-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Leu | Asp94Asn-Ser95Thr | wt | Cys14Thr | wt | Beijing |
43 | U6904-19 | Ser531Leu | Ser315Thr | wt | wt | wt | wt | wt | wt | Beijing | |
44 | U7033-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Leu | Ala90Val-Ser91Pro | wt | Gly10Ala | wt | Beijing |
45 | U7157-19 | wt | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | Beijing |
46 | U7156-19 | Ser531Leu | Ser315Thr | wt | wt | wt | wt | wt | wt | wt | Beijing |
47 | U5610-19 | wt | Ser315Thr | wt | wt | wt | wt | wt | wt | wt | Beijing |
48 | U5617-19 | wt | Ser315Thr | wt | wt | wt | wt | wt | wt | wt | Beijing |
49 | U5671-19 | Ser531Leu | Ser315Thr | wt | wt | Asp354Ala | wt | wt | Gly10Ala | wt | Beijing |
50 | U5707-19 | Ser531Leu | Ser315Thr | wt | wt | wt | wt | wt | wt | wt | Beijing |
51 | U00132-20 | Ser531Leu | Ser315Thr | wt | wt | wt | wt | wt | Gly37Thr | wt | Beijing |
52 | U00196-20 | wt | Ser315Thr | wt | wt | wt | wt | wt | wt | wt | Beijing |
53 | U5695-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | Ala1401Gly | Beijing |
54 | U5593-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | Beijing |
55 | U5391-19 | wt | Ser315Thr | wt | wt | wt | wt | wt | wt | wt | Beijing |
56 | U5312-19 | wt | Ser315Thr | wt | wt | Asp354Ala | wt | wt | wt | wt | Beijing |
57 | A2204-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Leu | wt | wt | wt | wt | Beijing |
58 | A1989-19 | wt | Ser315Thr | wt | wt | wt | wt | wt | wt | wt | Beijing |
59 | A2364-19 | Ser531Leu | Ser315Thr | wt | wt | Glu378Ala | wt | wt | wt | wt | Beijing |
60 | A5576-19 | wt | Ser315Thr | wt | wt | wt | wt | wt | wt | wt | Beijing |
61 | A5473-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | Asp94Tyr-Ser95Thr | wt | Cys14Thr | wt | Beijing |
62 | A5935-19 | wt | Ser315Thr | wt | wt | Asp354Ala | wt | wt | wt | wt | Beijing |
63 | A6771-19 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | Beijing |
64 | A7404-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
65 | A7233-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
66 | A7557-19 | Ser531Leu | wt | T15A | wt | Asp354Ala | wt | wt | wt | wt | Beijing |
67 | A7556-19 | Ser531Leu | wt | wt | wt | Asp354Ala | wt | wt | wt | wt | Beijing |
68 | A5617-19 | Ser531Leu | wt | wt | wt | Met306Val | wt | wt | wt | Ala1401Gly | Beijing |
69 | A5671-19 | wt | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | Beijing |
70 | A5707-19 | wt | Ser315Thr | wt | wt | wt | wt | wt | wt | wt | Beijing |
71 | A0032-20 | Ser531Leu | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | Beijing |
72 | A0096-20 | Ser531Leu | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
73 | A0128-20 | Ser531Leu | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
74 | A0141-20 | wt | Ser315Thr | wt | wt | Ala313Val | wt | wt | wt | wt | Beijing |
75 | A0142-20 | Leu511Pro | Ser315Thr | wt | wt | Met306Val | wt | wt | wt | wt | Beijing |
76 | A4895-19 | wt | Ser315Thr | wt | wt | wt | wt | wt | wt | Beijing | |
77 | A7845-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
78 | A0113-20 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
79 | A0101-20 | wt | Ser315Thr | wt | wt | Gly406Ser | wt | wt | wt | wt | Beijing |
80 | A1450-20 | Ser531Leu | Ser315Thr | wt | wt | Ala313Val | wt | wt | wt | Ala1401Gly | Beijing |
81 | U1550-19 | wt | Ser315Thr | wt | wt | Gly406Ser | wt | wt | wt | wt | Beijing |
82 | U2479-20 | Ser531Leu | Ser315Thr | wt | wt | wt | wt | wt | wt | wt | Beijing |
83 | U2150-20 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
84 | U6232-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
85 | A1753-19 | wt | Ser315Thr | wt | wt | wt | wt | wt | wt | Beijing | |
86 | A1875-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
87 | A2064-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
88 | A2058-19 | Asp516Ala | Ser315Thr | wt | wt | Glu378Ala | wt | wt | wt | Ala1401Gly | Beijing |
89 | A2090-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
90 | A5199-19 | wt | Ser315Thr | wt | wt | wt | wt | wt | wt | Beijing | |
91 | A6930-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
92 | A7025-19 | wt | Ser315Thr | wt | wt | wt | wt | wt | wt | wt | Beijing |
93 | A7232-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
94 | A6924-19 | wt | wt | wt | wt | wt | wt | wt | wt | Beijing | |
95 | A8060-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Beijing |
96 | A8059-19 | wt | Ser315Thr | wt | wt | Ala313Val | wt | wt | wt | wt | Beijing |
97 | A1458-20 | wt | wt | wt | wt | wt | wt | wt | wt | wt | LAM |
98 | A5720-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | LAM |
99 | U2720-20 | wt | wt | wt | wt | wt | wt | wt | wt | wt | LAM |
100 | A1876-19 | wt | wt | T15A | wt | wt | wt | wt | wt | wt | LAM |
101 | A1461-19 | Leu511Pro | wt | wt | wt | Met306Val | wt | wt | wt | wt | LAM |
102 | A1479-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | LAM |
103 | A1481-20 | His526Asn | wt | wt | wt | Met306Val | wt | wt | wt | wt | LAM |
104 | A1877-19 | wt | wt | T15A | wt | wt | wt | wt | wt | wt | LAM |
105 | A1590-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | LAM |
106 | A2198-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | LAM |
107 | A0097-20 | wt | wt | wt | wt | wt | wt | wt | wt | wt | T 1 |
108 | A0139-20 | wt | wt | wt | wt | wt | wt | wt | wt | wt | T 1 |
109 | U6172-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | T 1 |
110 | A3695-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Ural |
111 | A1754-19 | Asp516Ala | wt | wt | wt | wt | wt | wt | wt | wt | Ural |
112 | A0039-20 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Ural |
113 | U6151-19 | wt | wt | wt | wt | wt | wt | wt | wt | wt | Ural |
114 | U5054-19 | wt | wt | wt | wt | Asp94Ala-Ser95Thr | wt | wt | wt | Ural | |
115 | U5055-19 | wt | wt | wt | wt | wt | wt | wt | wt | Ural | |
116 | U00139-20 | wt | wt | wt | wt | wt | wt | wt | Gly10Ala | Ural | |
117 | A2751-19 | wt | wt | wt | wt | Met306Val | wt | wt | wt | wt | Ural |
118 | A2563-19 | wt | wt | wt | wt | wt | wt | wt | wt | Ural | |
119 | A2805-19 | wt | wt | wt | wt | wt | wt | wt | wt | Ural | |
120 | A2401-19 | wt | wt | wt | wt | wt | wt | wt | wt | Ural | |
121 | A3191-19 | wt | wt | wt | wt | wt | wt | wt | wt | Ural | |
122 | A4456-19 | wt | wt | wt | wt | Ala90Val-Ser91Pro | wt | wt | wt | Ural | |
123 | A2816-19 | wt | wt | wt | wt | wt | wt | wt | wt | Ural | |
124 | A2954-19 | wt | wt | wt | wt | wt | wt | wt | Cys12Thr | Ural | |
125 | A2566-19 | wt | wt | wt | wt | Asp94Asn-Ser95Thr | wt | wt | wt | Ural | |
126 | A2798-19 | wt | wt | wt | wt | wt | wt | wt | wt | Ural | |
127 | A3701-19 | wt | wt | wt | wt | wt | wt | wt | wt | Ural | |
128 | A3153-19 | wt | wt | wt | wt | wt | wt | wt | wt | Ural | |
129 | A1750-20 | wt | wt | wt | wt | wt | wt | wt | wt | wt | EAL |